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UICC World Cancer Congress 2006

Bridging the Gap: Transforming Knowledge into Action

July 8-12, 2006, Washington, DC, USA

Monday, 10 July 2006 - 12:00 PM
85-46

Genetic Polymorphisms of MYH, ΑPE1, NΑT2 and Their Association with Colorectal Cancer in a Japanese Population

Kana Yoshida1, Mayumi Kasahara1, Aiko Miyaishi1, Yasunori Osawa1, Kayo Osawa1, Natsuko Inoue2, Kenichi Tanaka3, Masahiro Yamamoto3, Etsuji Shimada4, Yoshiki Tabuchi1, and Juro Takahashi1. (1) Graduate School of Medicine, Division of Health Sciences, Kobe University, 7-10-2, Tomogaoka Suma-ku, Kobe, 654-0142, Japan, (2) School of Medicine, Tokyo Medical and Dental University, (3) Surgery, Kobe Rosai Hospital, (4) Surgery, Kobe Medical Center

Objective: Detoxification enzyme N-acetyltransferase 2 (NAT2) and DNA repair enzymes (MYH, OGG1, APE1) play important role in the development of various kind of cancer. To investigate the polymorphisms of NAT2, MYH, OGG1 and APE1 genes, and their association with the risk of colorectal cancer (CRC), we examined the genotypes of these genes in a Japanese population and their association with CRC was evaluated.

Methods: 70 CRC patients and 121 non-cancer controls were included in this study. According to their Brinkman Index (BI), the individuals were divided into non-smoking (BI=0) and smoking (100≤BI≤1200) groups. The genotypes of NAT2, MYH, OGG1 and APE1 were determined by using PCR-RFLP method. Fisher′s Χ2-test was applied to compare the frequencies of genotypes in different groups and odds ratio (OR) was also calculated.

Results: In non-smoking group, frequency of rapid genotype of NAT2 was higher in CRC patients than controls (OR=5.9, 95%CI 2.0-17.6, P=0.001). And frequency of Gln/Gln genotype of MYH was higher in CRC patients than controls in non-smoking group (OR=5.7, 95%CI 1.4-22.8, P=0.011) and in smoking group (OR=10.4, 95%CI 2.1-50.4, P=0.002). In addition, in smoking group, frequency of Asp/Glu genotype of APE1 was higher in CRC patients than controls (OR=5.9, 95%CI 2.2-16.3, P=0.0003). Our findings suggested that polymorphisms of NAT2, MYH and APE1 gene were associated with risk of CRC in a Japanese population, and their association was effected by smoking.


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