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UICC World Cancer Congress 2006Bridging the Gap: Transforming Knowledge into ActionJuly 8-12, 2006, Washington, DC, USA |
Tuesday, 11 July 2006 - 12:00 PM
167-45
Incidence of Fusion Gene Transcripts E2a-Pbx, Tel-Aml, Mbcr-Abl and Mll-Af4 in South Indian Acute Lymphoblastic Lleukemias
Methods:Total RNA was isolated from Bone marrow/ Peripheral blood of 67 B-ALL patients at presentation , reverse transcribed to cDNA , PCR done to detect the fusion gene transcripts and sequenced.
Results: Eleven of 67 B-ALL (16.4%) patients revealed one of the 4 risk stratifying translocations. Of the 4 patients with E2A-PBX translocation , one patient died without achieving remission and 3 continue to be in clinical and hematological remission. In 4 B-ALL patients with TEL-AML translocation , 2 declined treatment, one patient died without achieving remission and other continues to be in clinical and hematological remission. Of the 2 mBCR-ABL positive patients one patient is in clinical and hematological remission while the other relapsed after achieving clinical and hematological remission. A one year old child with MLL-AF4 translocation continues to be in clinical and hematological remission. Sequencing revealed no variants in breakpoints.
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