Bridging the Gap: Transforming Knowledge into Action
July 8-12, 2006, Washington, DC, USA
Tuesday, 11 July 2006 - 12:00 PM 167-23
Suppression of Tumor Growth by a Protease Inhibitor, Camostat Mesilate: an Experimental Study
Nobuo Murata, PhD1, Tsuyoshi Suzuki, MD2, Tomonori Oosawa2, and Hideyuki Ishida, PhD2. (1) Department of Surgery, Teikyo University Mizonokuchi Hospital, 3- 8- 3, MIzonokuchi, Takatsu-ku, Kawasaki City, Kanagawa, 213-8507, Japan, (2) Department of Surgery, Saitama Medical Center, Saitama Medical School, 1981, Kamoda-Tsujido, Kawagoe City, Saitama, 350-8550, Japan
Objective:Several investigators have reported the suppressive effect of protease inhibitors on tumor growth. We investigated whether Camostal mesilate, a synthetic protease inhibitor, could suppress tumor growth in an experimental model. Methods:Male Balb/C mice (n=36) were fed either a diet containing Camostal mesilate (100mg/100g) (group1) or the standard mouse diet (group 2 and group3) for 10 days. On the 11 th day, colon 26 carcinoma was implanted in the back subcutaneously. Mice of group 2 were fed food containing Camostat mesilate from the 11 th day. All mice were sacrificed on the 21 st day to examine the growth of the tumor and measure several citokines in blood. Results:The tumor volumes of groups 1,2 and 3 was 1136 +/- 665 mm3 (mean +/- SD), 2123 +/- 1053 and 2317 +/- 883, respectively. The tumor volume in group 1 was significantly smaller then those in the other groups. The tumor weight in group 1 was also lower than those in the other two groups. There were no differences of cytokine levels in blood among 3 groups. Conclusion: This study suggests that early oral administration of Camostat mesilate suppresses tumor growth.