UICC World Cancer Congress 2006

Objective:The study was to determine the value of serum total CK level and clinical significance for Extrahepatic Bile Tract Cancer (EBTC).

Methods: This is a retrospective analysis of 45 populations that were managed care database of serum CK using biochemical autoanalyzer measured. All upper or lower GI tumors with liver metastasis and gallstone was excluded. A total of 18 EBTC included Gallbladder cancer (n=4) Cholangiocarcinoma (n=6) and cancer of ampullary of Vater (n=8) with a mean age of 52 years old (range: 46-72).

Results: Serum CK value was 28.71±6.53u/L in 27 non-EBTC, whereas, it was 9.56±3.80u/L (X±SD) in EBTC.Therefore, serum C K in patients with EBTC was lower than control subjects (P<0.005) i.e. Serum CK for EBTC was lower 3- fold than non- EBTC. Ten cases (55%)of 18 were operated. Five (50%) of ten cases serum CK disappeared (0 u/L). Two weeks later, Four ((40%) of ten cases serum CK had elevated to normal level. Our finding suggest that serum lower CK level is reflected anti-tumor effect.

Conclusions: Low serum CK appearance not only to be valuable one of diagnostic index of EBTC, but also it may prove potential biochemical marker in the evaluation of prognosis for EBTC.