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UICC World Cancer Congress 2006
Bridging the Gap: Transforming Knowledge into Action
July 8-12, 2006, Washington, DC, USA
Methods: Between 1997-2002, 69 patients were operated on radically, with systematic mediastinal lymph node dissection, for stage T2N0M0 squamous cell lung cancer. Biologic prognostic factors such as: expression of g53 mutation, BCL-2, BAX and VEGF, tumor cell ploidy, S-phase cell fraction, allelic imbalance and instability of microsatellite 32-36th loci on chromosome 1p were examined in the resected specimens. The patients were retrospectively divided into 2 groups: the first group included 31 patients, in whom progression of disease was detected within 3 years after surgery (unfavorable prognosis) and the second group, which consisted of 38 patients, who survived 3 years without any evidence of disease (favorable prognosis).
Results: Statistical monfactorial analysis showed (p<0.05) that unfavorable prognosis was associated with the presence expression of g53 mutation and VEGF, absence of expression BCL-2 and BAX, tumor cell aneuploidy, S-phase cell fraction of more than 10%, allelic imbalance and instability of microsatellite 32-36th loci on chromosome 1p. Survival calculated by multifactorial regression analysis, taking into account above-mentioned factors of prognosis, coincided with retrospectively assessed survival of the same patients. Thus, biology prognostic factors may be used for individual prognosis of survival after surgery in patients with stage T2N0M0 squamous cell lung cancer and for indidvidual planning of treatment.