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UICC World Cancer Congress 2006
Bridging the Gap: Transforming Knowledge into Action
July 8-12, 2006, Washington, DC, USA
Methods: We examined the phenotypic expression of cell cultures established through the immortalization of non-malignant (RC-165N and RC-170N) and malignant (957E, RC-58T and RC92a) primary human prostate epithelium with telomerase, the gene that prevents cellular senescence.
Results:Examinations of these cell lines for their morphologies and proliferous capacities, for their abilities to grow with or without serum, for their response to androgen stimulation, for their growth above the agar layer, and their ability to form tumors in SCID mice, suggests that they may serve as valid, useful tools for the elucidation of prostate tumorigenesis. The chromosome alterations observed in these immortalized cell lines expressing aspects of the malignant phenotypes imply that these cell lines accurately recapitulate the genetic composition of primary prostate tumors.