UICC World Cancer Congress 2006

Objective: Incidence of endometrial cancer in region of Vojvodina, part of Republic of Serbia, in 1985-2001 was 15-20/100.000. The main goal of this study was to examine statistical significance of clinical-sonography scoring system ONCO 1 as a noninvasive diagnostic method for endometrial cancer vs. TVS score.

Methods: A 122 patients with postmenopausal bleeding were included. Transvaginal sonography was performed before curettage. Patients were divided into a group A (with endometrial cancer) and B (benign endometrial pathology), after final histopathological findings obtained by curettage. ONCO 1 scoring system was created. Also TVS score using only endometrial thickness was created, too. Using test for diagnostic accuracy and receiver operating characteristic (ROC) curve evaluations for ONCO 1 and TVS score was performed.

Results: Patients with endometrial cancer were older: 64.49 vs. 58.81 years, length of corpus uterus was longer: 6.41 vs. 5.25 cm, and postmenopausal period was longer: 13.67 vs. 9.11 years. All parameters were statistically significant. Average value of clinical-sonography scoring system ONCO 1 in group A was 9.14, SD ± 2.32 and in group B was 7.13, SD ± 3.07. There was found statistically significant difference between group A and group B of patients using this scoring system. Average value of TVS score in group A was 2.53, SD +/-0.75 and in group B: 2.35, SD+/- 1.05 without any statistically significant difference. It was possible to distinguish high-risk patients with neoplasia from those with benign changes of endometrium using ONCO 1. Less sensitivity showed TVS score without statistical significance among these two groups.