UICC World Cancer Congress 2006

Objective: -To study the several retinoids (derivatives of vitamin A)that inhibit cancer cell growth in lung cancer. -To evaluate the tobacco-related cancer prevention by Vitamin A derivative.

Methods: This study was done between Jan.2000 and Feb. 2004 in the Radio Isotope Centre Khartoum(RICK). We respectively analyzed 158 Sudanese smokers male and female in >18 years age, suffering from lung cancer were attending to Radio Isotope Center Khartoum to having treatment, against 17 apparently healthy individual setting as control groups. Data of all patients( lung cancer) and control were collected using questionnaire included the information of age, sex, place of original, prognosis, complications and Laboratory investigations. Laboratory studies were done to all patients to evaluate the several retinoids (derivatives of vitamin A) that inhibit cancer cell growth in lung cancer.

Results: The induction of apoptosis may enhance cancer prevention (72%) of cases. The one retinoid, 6-[3-(1-adamantyl)-4-hydro-xyphenyl)]-2-naphthale-necarboxylic acid (abbreviated AHPN), showed an inhibits of lung cancer cell growth and induces lung cancer cell apoptosis (87%). This study indicated that AHPN exerts its anticancer activity without interacting with the retinoid receptors, an advantage because toxic effects are less likely to cause side effects. Furthermore, AHPN is far more effective (20- to 100-fold) than other retinoids, including the natural retinoid trans-retinoic acid, in inhibiting growth of lung cancer cells in culture. Preliminary studies with SR11389, the AHPN analog, indicate that this objective is reasonable. New compounds will first be evaluated for their ability to inhibit lung cancer cell growth compared to normal lung cell growth.