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UICC World Cancer Congress 2006
Bridging the Gap: Transforming Knowledge into Action
July 8-12, 2006, Washington, DC, USA
Methods:In 2005 we examined 16 patients with breast cancer suspected to have PNS, hospitalized at Breast Cancer Clinic,Institute of Oncology in Warsaw, Poland.
Results:The immunofluorescence test was positive in 9 patients (56%) and in 3 of them in the WB test clearly positive results were obtained. In 5 patients a very weak reaction was observed and in 1 patient the result of WB was completely negative.The following paraneoplastic neurological syndromes were observed in patients with a positive result of the IF test: cerebellar degeneration, brainstem encephalitis, encephalomyelitis combined with sensory neuropathy, myastenic syndrome, sensory neuropathy, polyneuropathy Guillain-Barre. CONCLUSIONS: Our analysis indicates that the investigation of the presence of ANA in the serum may be helpful and valuable in the diagnostics of PNS in patients with breast cancer. The types of ANA correspond with individual paraneoplastic neurological syndromes.