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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Short Term Effects of Smoking Cessation on Blood Antioxidant Parameters and Paraoxonase Activity in Healthy, Asymptomatic Long-Term Cigarette Smokers

Berrin Imge Erguder, MD, PhD1, Toker Erguder, PhD2, Ceylan Ozkan, MD3, Nergiz Bozkurt3, Kazim Soylu1, Erdinç Devrim1, and Ilker Durak1. (1) Department of Biochemistry, Ankara University School of Medicine, Ankara Universitesi Tip Fak. Biyokimya AD Dekanlik Binasi, Sihhiye, Ankara, 06100, Turkey, (2) Mental Health Department of Primary Health Care General Directorate, Substance Dependence Section, Saglik Bakanligi Temel Saglik Hizmetleri Genel Müdürlügü, B Blok Kat 4 Sihhiye, ANKARA, 06340, Turkey, (3) MAN Ankara-Turkey, CUBUK, ANKARA, 06600, Turkey

Objective: The aim of this study was to compare short term effects of smoking cessation on blood oxidant/antioxidant status, lipid peroxidation, lipid/cholesterol levels and paraoxonase activity.

Methods: Sixteen healthy, asymptomatic long-term cigarette smokers (mean age: 35±9 years) participated in the study in the smoking cessation program. After and before smoking cessation, subjects were examined for oxidant/antioxidant status, lipid peroxidation, lipid/cholesterol, paraoxonase activity, breath carbon monoxide levels and blood carboxyhaemoglobin values.

Results: When compared to previous values, subjects were revealed statistically significant decreases in the malondialdehyde and carbon monoxide levels after 4 weeks of smoking cessation. HDL (High density lipoprotein) / LDL (Low density lipoprotein) cholesterol ratio was found to be increased. Additionally significantly increased paraoxonase activity was observed in the blood samples obtained after cigarette cessation period. Results suggest that smoking cessation reduces serum lipid peroxidation products and carbon monoxide levels, and increases blood paraoxonase activity and HDL/LDL ratio.