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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Is Smoking Cessation with Bupropion Successful Enough?

Antigona Carmen TROFOR, Ph.D., Ass.Prof., Traian Mihaescu, PH.D., Professor, and Valentina Esanu, MPH. Pneumology, Clinic of Pulmonary Diseases,University of Medicine,Iasi,Romania, 30, Dr. Iosif. Cihac Street, Zip code 700115,Iasi,Romania, Home adress:11. Victor Babes Street, Zip:700464, Iasi, Romania

Objective: To evaluate outcomes of smoking cessation with bupropion, as single terapeutical alternative in smoking cessation.

Methods: Patients undergoing bupropion terapy for 2 months and called in follow-up for 6 months were reviewed.

Number of packs/year, nicotine dependency scores. previous quit attempts, coexistent alcoholism or depressive symptoms and smoking associated diseases were annalysed.

In follow-up we registered withdrawal symptoms, side effects of bupropion and monitored abstinence by measuring carbon monoxide in the exhaled air.

Results: 68 patients (42 M, 26 F), of mean age 38 years, heavily addicted to nicotine( Fagerstrom/7+- 2), were prescribed bupropion for 8 weeks. 62.3% had previously tried to quit smoking and 7% had already failed with bupropion. 24% admitted alcohol concomitent abuse, 22% depression history, 20% had also COPD and 14.6% cardiovascular involvement.

The treatment was completely achieved in 64%. Drop-outs were related to withdrawal syndrome ( 28%) and headaches(46.8%).No patient in the second bupropion terapy cure has discontinued treatment.

Succes rate was: continuous abstinence in 28% and smoking reduction in 14.2%.

Conclusions: Outcome of bupropion terapy was encouraging, but under our expectancies, considering the unique pharmacological terapeutical alternative bupropion represents now in Romania.