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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Does the C-Reactive Protein Level Play an Important Role in Smoking Patients with Graves' Ophthalmopathy ?

Ewa Florek, PhD1, Agata Czarnywojtek, MD2, Izabela Warmuz-Stangierska, MSc2, Barbara Rabska-Pietrzak, MD3, Peter Kurdybacha, MD2, Jerzy Sowi˝ski, MD2, and Wojciech Piekoszewski, PhD4. (1) Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Dojazd 30, Poznan, 60-631, Poland, (2) Department of Endocrinology, University of Medical Sciences, Przybyszewskiego 49, Poznan, 60-355, Poland, (3) Department of Paediatric Endocrinology and Diabetology, University of Medical Sciences, Szpitalna 27/33, Poznan, 60-572, Poland, (4) Institute of Forensic Research, Westerplatte 9, Krakow, 31-033, Poland

Objective: C-reactive protein (CRP) belongs to the inflammatory proteins and it is a marker of inflammation and tissue damage.The aim of this study was to evaluate levels of CRP in smoking patients with Graves' ophthalmopathy (GO).

Methods: We analysed 75 smoking patients with different degrees of severity of GO (70 females, 5 males, age 34▒16). As a control we used 35 non-smoking patients with GO (31 females, 4 males, age 31▒7). Measurement of the anti-TSH receptor antibodies (TRAb) was performed in the serum by a radioreceptor assay. The hsCRP method is based on a particle enhanced turbidimetric immunoassay technique. Smoking status was determined by the Fagerstr÷m test and Brinkman's index.

Results: Tobacco smoking induces inflammantory process in patients with Graves' ophthalmopathy what was indicated by higher concentration of hsCRP in GO smokers patients in comparison to the control, but the difference was not statistically significant (9.48▒7.67 mg/l vs. 8.34▒18.30 mg/l). We didn't find statistically significant differences in anti-TSH receptor antibodies between the two groups (12.4▒3.7 vs. 11.8 ▒ 3.2). There was no statistical correlation between hsCRP and TRAb.