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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Effect of Cumulating of Heavy Metals and Zinc in Placenta of Smoking Woman on Newborn Body Weight

Wojciech Piekoszewski, PhD1, Ewa Florek, PhD2, Grzegorz H. Breborowicz, MD3, and Malgorzata Wolny, MSc2. (1) Institute of Forensic Research, Westerplatte 9, Krakow, 31-033, Poland, (2) Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Dojazd 30, Poznan, 60-631, Poland, (3) Perinatology and Gynaecology Clinic, University of Medical Sciences, Polna 33, Poznan, 60-535, Poland

Objective: The aim of this paper is to estimate the concentration of heavy metals and zinc in the urine and placenta of women smoking tobacco during pregnancy, and correlating it with the level of cotinine and a birth body weight.

Methods: Concentration of cotinine was measured by HPLC and metals by AAS method.

Results: The conducted research with participation of 143 delivering women showed that an average concentration of cotinine in the urine of smoking women, was 985+/-843 ng/mg of creatinine. The concentration of cadmium but not lead in the urine of smoking women was statistically significantly higher than in non-smoking woman. The concentration of cadmium and zinc in placenta was higher in the smokers (Cd 0.104+/-0.048microg/g; Zn 49.7+/-6.37microg/g) than in the non-smokers (Cd 0.061+/-0.031microg/g; Zn 40.9+/-5.77microg/g). The concentration of cadmium in placenta was slightly correlated with the concentration of cotinine in the urine. The birth body weight of the newborns of smoking women (2875+/-852.3g) was significantly lower than those of non-smoking women (3343.9+/-801.7g), but was neither correlated with the concentration of heavy metals in the urine and placenta nor the concentration of zinc in the placenta. However, the conducted research confirmed the lowering of newborns' body weight and increase in the level of cadmium and zinc in placenta, as a consequence of smoking tobacco, it did not show, the impact of its accumulating on the birth body weight.

Financed by the State Committee for Scientific Research, grant no. 2 P05E 103 26