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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Risk Factors Associated with Cervical Cancer: Results of a Case Control Study

Abdoul Aziz Kasse, MD, Surgical Oncology, Cheikh Anta DIOP Universiry Cancer Center, Hopital Aristide Le Dantec Avenue Pasteur, Dakar, Senegal

Objective: Human Papilloma virus (HPV) infection is the central risk factor of cervical cancer, the most common cancer in Senegalese women. More than 38% of Senegalese women have HPV infection. In industrialized countries, some other co factors (including tobacco exposure) have been identified. To identify the risk factors in our country, we conducted a prospective case control study.

Methods: We included 53 cervical cancer cases matched with 178 controls. Consent form, history of exposure to risk factors was taken. All cases and controls had colposcopy, HPV and HIV testing by PCR.

Results: Univariate analysis identified many risk factors including: HPV infection (p = 0,00001), Younger age at tobacco addiction (p =0,000), number of cigarettes (p= 0,000), Exposure to indoor smoke (p = 0,0000), lack of use butane (p =0,0000), exposure to pesticides (0,000), number of sex partners (p = 0,000), low number of cups of green tea (p = 0,001), lack of barrier contraception use (p = 0,00003), weight loss (p = 0,00000). Multivariate analysis identified 7 independent risk factors: HPV infection (p = 0,0050), lack of barrier contraception (p = 0,0058), lack of use of butane (p = 0,006), non urbanized patients (p = 0,0008), number of pregnancies (p = 0,0268), low number of cups of green tea (p = 0,001), weight loss (p = 0,0003). Conclusion HPV infection remains a central factor. The cofactors include cigarette smoking and exposure to indoor smoke from cooking fires.