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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Is the G223a Polymorphism of the Leptin Receptor Gene Associated with Weight Gain after Smoking Cessation: Preliminary Results

Jose M. Chatkin, MD, PhD, Graziela Oliveira, and Maristela Taufer. School of Medicine, Pontificia Universidade Catolica do Rio Grande do Sul, Av.Ipiranga 6690 3rd floor, Porto Alegre, Brazil

Objective: Studies have demonstrated that an inverse relationship exists between the tobacco use and body weight and that smoking cessation is accompanied by weight increase. The role of leptin, or of its receptors is under investigation. The aim of this study was to evaluate the association of the Gln223Arg polymorphism of the leptin receptor gene, BMI and smoking status.

Methods: a cross-sectional study was accomplished with 288 individuals (174 men and 114 women), mean age of 34.6+11 years, divided in 3 groups: no smokers, smokers and former-smokers. A completed a structured questionnaire containing demographic, socioeconomic and cultural data, and details of the smoking habit of the volunteer. We also evaluated nicotine dependence by , Fargestrom Test of Nicotine Dependece, weigh and height. Blood sample was collected for genetic analysis of the Gln223Arg polymorphism of the leptin receptor gene through the technique of PCR/RFLP.

Results: smoking status: no smokers:106(36.8%), smokers: 99 (34.4%), former-smokers 83 (28.8%). Mean BMI in the groups was: no smokers 25.7+4.0 kg/m2, smokers: 25.7+3.9 kg/m2, former-smokers: 26.0+3.4 kg/m2 (p=0.805). Genotypic frequencies of the Gln223Arg polymorphism of the leptin receptor gene were GG: 38.9%, AG: 51.4% and AA: 9.7%. There were no significant differences in the the genotypic frequencies and the three groups of tobacco status (p=0.401).However, a significant association was found when BMI was included in such analyses. CONCLUSION: this study found association among the Gln223Arg polymorphism of the leptin receptor gene, tobacco status and BMI, when analyzed together. The association among the smokers with genotype AA and higher BMI was significant.