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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

N-Nitrosamines and Its Precursor Compounds in Smokers and Non-Smokers in Calabar Metropolis,Calabar,Nigeria

Edmund R. Egbe, M.Sc, Chemical Pathology, University of Calabar, Nigeria, No 4A Barracks Rd, Calabar, Nigeria

Objective: To determine the serum level of N-Nitrosamines and its precursor compounds in smokers and non-smokers in Calabar Metropolis.

Methods: Serum nitrite,nitrate and N-nitrosamine levels were estimated in seventy smokers and fifty non-smokers using physiochemical and spectrophotometric techniques. All subjects used were healthy volounteers.

Results: The findings show that the smokers have significantly higher (p<0.05) levels of mean serum nitrite and mean serum nitrosamine when compared with the non-smokers. The mean serum nitrate concentration in smokers was significantly lower(p<0.05) than that of the non-smokers. Amount of cigarette intake amd smoking years correlated positively(r =0.59,p<0.05) with serum nitrite concentration, also serum nitrite levels correlated negatively with serum nitrate levels but positively with serum N-nitrosamine levels amongst smokers.