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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA

Thursday, July 13, 2006 - 12:00 PM

Tobacco and Lung Cancer: a Case Control Study in a Metropolitan Area of South-Eastern Brazil

MIRIAN CARVALHO SOUZA, MPH, Epidemiology Unit, NATIONAL CANCER INSTITUTE, BRAZIL, Av. Vicente de Carvalho, 653 casa 19, CEP 21210-000, Rio de Janeiro, Brazil, Valeska Figueiredo, MPH, Epidemiology Unit, Instituto Nacional de Câncer, Rua dos Inválidos 212/3 andar, Rio de Janeiro, Brazil, and Márcia Pinto, MSc, Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rua dos Inválidos, 212/4o andar, Centro, Rio de Janeiro, 20231020, Brazil.

Objective: Evaluate the risk to develop lung cancer among smokers in Rio de Janeiro, Brazil.

Methods: A hospital based nested case-control study was carried in Rio de Janeiro, Brazil. The data is part of a multicentric research carried in Chile, Colombia and Mexico, with support of the Pan-American Health Organization. Cases had been diagnosed by biopsy. For each case two controls was nested by sex, age and city of residence. The controls did not have antecedents of cancer, acute myocardial infarction, chronic obstructive pulmonary disease (COPD) and other selected illnesses. The information of cases and controls had been collected through a questionnaire applied by trained interviewers. In this paper smokers are considered those who reposted smoking at least 100 cigarettes in life. For the adjusted analysis familiar history of COPD and alcohol use was used. Estimates of odds ratio had been calculated through a conditional logistic regression using the software Stata8.0.

Results: A total of 251 cases (82,9% smokers) and 502 controls (45,0% smokers) were interviewed. The odds ratio indicates that in this population, the risk to develop lung cancer, among smokers is 7.5 (IC95%, 4.8-11.7) times higher than non-smokers. When stratified by gender the estimates are 7.9 (IC95%, 4.8-13.0) and 6.0 (IC95%, 2.3-15.7) for females and males respectively. The adjustments for familiar history of COPD and alcohol use had not been significant (0.05). The results indicate an increased risk for development of lung cancer among smokers of both genders.