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The 13th World Conference on Tobacco OR Health

Building capacity for a tobacco-free world

July 12-15, 2006, Washington, DC, USA



Thursday, July 13, 2006 - 12:00 PM
13-242

Active Smoking and the Risk of Pulmonary Metastasis in Adult Women with Breast Cancer

DORIN VANCEA, PhD, Clinic of Pulmonary Diseases, Hospital "Dr.V.Babes" Timisoara, 13, Gheorghe Adam Street, Timisoara, Romania

Objective: To determine in a clinical study, whether tobacco smoke may contribute as a risk of developing pulmonary metastasic disease (PMD), among women with breast cancer. To provide that treatment for achieving smoking cessation, must become part of the standard therapy for women who are still smoking at the time of breast carcinoma diagnosis.

Methods: There where investigated 186 women with unilateral breast cancer: a study group of 62 patients with PMD and a control group of 124 women without PMD. The two groups where compared to determine the odds regarded to cigarette smoking behaviour.

Results: 46,7% of the study patients vs. 32% of the control patients were ever smokers; 33,8% of the study patients were current smokers at the time of PMD diagnosis vs. 25% of the control patients. Compared with never smokers, the unadjusted odds ratio for PMD was 1.65 (95%CI, 1.16-2.21 ) for ever smokers and 1.7 (95%CI, 1.23-2.47 ) for current smokers. The increased number of cigarettes and years of smoking was associated with a greater risk of PMD: compared with never smokers, the unadjusted odds ratios were 1.98 (95%, CI 1.32-2.78 ) for 11-20 pack-year of smoking and 2.09 (95%CI, 1.42-2.74 ) for women who smoked > 20 pack-year. The study provides evidence that active smoking may play a role in developing PMD among women with breast cancer. The odd ratios were statistically significantly increased, in patients who had longer duration or greater intensity of smoking.